4-Fluorobenzaldehyde → [2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-(4-fluoro-benzyl)-amine

HRID 2169350노트

반응식

HRID 2169350 반응식
[Si:1]([O:8][CH2:9][CH2:10][NH:11]C1CCCC1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=1.[Si](OCCN)(C(C)(C)C)(C)C>>[Si:1]([O:8][CH2:9][CH2:10][NH:11][CH2:22][C:21]1[CH:24]=[CH:25][C:18]([F:17])=[CH:19][CH:20]=1)([C:4]([CH3:6])([CH3:7])[CH3:5])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 680234-FluorobenzaldehydeHCID 529218(2-Aminoethoxy)(tert-butyl)dimethylsilaneHCID 86725959[2-(Tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopentylamine

생성물 1

HCID 59688027[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-(4-fluoro-benzyl)-amine수율 35.03%

실험 절차

This compound was prepared following the same method as described for [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopentyl-amine (8e) from 4-fluorobenzaldehyde (1 g, 8.06 mmol) and 2-(tert-butyl-dimethylsilanyloxy)-ethylamine (8c) (1.8 g, 10.48 mmol). The product was obtained as a light yellow liquid (800 mg, 35.03%).

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-0443ed13e21440c3bff7b3c18fc0528c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045486B2

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