Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

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반응 단계

(S)-tert-Butyl 4-(1-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 17, step (i), 150 mg) in dichloromethane (15 mL) was treated with Burgess' reagent (100 mg) and stirred for 18 h. The reaction mixture was evaporated to a residue (145 mg) and used crude in the following step.

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