HCID 178455251, 화합물 → HCID 178519980, 화합물

HRID 2169445노트

반응식

HRID 2169445 반응식
OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(N3C4=NC=CC=C4C=C3)CCCC2)N=1)=O.[Si]([O:45][CH2:46][CH2:47][N:48]([CH2:81][CH:82]1[CH2:84][CH2:83]1)[C:49]([C:51]1[C:56]([O:57][CH2:58][C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=2)=[C:55]([OH:65])[N:54]=[C:53]([CH2:66][C:67]2([N:72]3[C:76]4=[N:77][CH:78]=[CH:79][CH:80]=[C:75]4[CH:74]=[CH:73]3)[CH2:71][CH2:70][CH2:69][CH2:68]2)[N:52]=1)=[O:50])(C(C)(C)C)(C)C>>[CH:82]1([CH2:81][N:48]([CH2:47][CH2:46][OH:45])[C:49]([C:51]2[C:56]([O:57][CH2:58][C:59]3[CH:60]=[CH:61][CH:62]=[CH:63][CH:64]=3)=[C:55]([OH:65])[N:54]=[C:53]([CH2:66][C:67]3([N:72]4[C:76]5=[N:77][CH:78]=[CH:79][CH:80]=[C:75]5[CH:74]=[CH:73]4)[CH2:68][CH2:69][CH2:70][CH2:71]3)[N:52]=2)=[O:50])[CH2:84][CH2:83]1

참가 물질

3

반응물 2

HCID 178455251HCID 178455251, 화합물HCID 178484643HCID 178484643, 화합물

생성물 1

HCID 178519980HCID 178519980, 화합물

실험 절차

5-Benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid cyclopropylmethyl-(2-hydroxyethyl)-amide (414) was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-methyl-amide (406) from 5-benzyloxy-6-hydroxy-2-(1-pyrrolo[2,3-b]pyridin-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-cyclopropylmethyl-amide (413) (170 mg, 0.26 mmol) and the product was obtained as white sticky solid (140 mg, crude).

후처리

  1. customthe product was obtained as white sticky solid (140 mg, crude)

출처 및 근거

ORD 기록
ord-0fa7ca02f4164890b79aaa1d16089e0a
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045486B2

반응 노트

불러오는 중…