Ethyl Acetate → (1-Pyridin-2-yl-cyclopentyl)-methanol

HRID 2169462노트

반응식

HRID 2169462 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:12](O)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1.C(OCC)(=O)C>O1CCCC1.CCCCCC>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([CH2:12][OH:13])[CH2:11][CH2:10][CH2:9][CH2:8]1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 690708191-Pyridin-2-yl-cyclopentanecarboxylic acid

생성물 1

HCID 83683266(1-Pyridin-2-yl-cyclopentyl)-methanol

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8058Hexane용매

실험 절차

To a stirred solution of 1-pyridin-2-yl-cyclopentanecarboxylic acid (431) (5 g, 26.178 mmol) in tetrahydrofuran was added BH3.tetrahydrofuran (1M) (52.36 mL) at 0° C. and stirring was continued for 1 h, then this reaction mixture was allowed to stir at room temperature for 5 h while silica thin layer chromatography was performed (50% ethyl acetate in Hexane; Rf=0.5).

출처 및 근거

ORD 기록
ord-657fc6804d084d32ac8b2c2988d25268
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045486B2

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