1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile → 1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde

반응식

[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([C:18]#N)[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.FC(F)(F)C1C=CC(C2(C=[O:36])CCCC2)=CC=1>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([CH:18]=[O:36])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

참가 물질

반응물 2

HCID 102671981-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile

HCID 218996431-(4-Trifluoromethyl-phenyl)-cyclopentanecarbaldehyde

생성물 1

HCID 867261091-(3,5-Bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde

실험 절차

1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde (456) was synthesized as a colourless liquid from 1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbonitrile (455) following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbaldehyde (238).

출처 및 근거

ORD 기록: ord-2a8cab4be8d94141a4c9b489cf2b80d3
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09045486B2

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