Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(1-cyano-2-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

HRID 216951노트

반응식

HRID 216951 반응식
[NH2:1][C:2](=O)[C@@H:3]([NH:22][C:23]([C:25]1([NH:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1)=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:19]=[C:18]3[C:14]([CH2:15][C:16](=[O:21])[N:17]3[CH3:20])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.CC[N+](S(N=C(OC)[O-])(=O)=O)(CC)CC>ClCCl>[C:2]([C@@H:3]([NH:22][C:23]([C:25]1([NH:31][C:32](=[O:38])[O:33][C:34]([CH3:36])([CH3:35])[CH3:37])[CH2:26][CH2:27][O:28][CH2:29][CH2:30]1)=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:19]=[C:18]3[C:14]([CH2:15][C:16](=[O:21])[N:17]3[CH3:20])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)#[N:1]

참가 물질

4

반응물 2

HCID 2724994Methyl N-(triethylammoniosulfonyl)carbamateHCID 59568615(S)-tert-Butyl 4-(1-amino-3-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

생성물 1

HCID 59568567(S)-tert-Butyl 4-(1-cyano-2-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of (S)-tert-butyl 4-(1-amino-3-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 21, step (i), 44 mg) in dichloromethane (5 mL) was treated with Burgess' reagent (25 mg) and stirred at room temperature for 24 h. The reaction was diluted with dichloromethane (50 mL) and washed with water (50 mL). The combined organic extracts were dried over magnesium sulfate and evaporated in vacuo to the sub-titled compound (35 mg).

후처리

  1. washwashed with water (50 mL)
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. customevaporated in vacuo to the sub-titled compound (35 mg)

출처 및 근거

ORD 기록
ord-ba6ac62e435047aab144e8e2d20a3316
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193239B2

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