4-Heptanol → 2-Amino-6-(heptan-4-yloxy)benzonitrile

반응식

[CH3:1][CH2:2][CH2:3][CH:4]([OH:8])[CH2:5][CH2:6][CH3:7].[NH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14](F)[C:11]=1[C:12]#[N:13]>>[NH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([O:8][CH:4]([CH2:5][CH2:6][CH3:7])[CH2:3][CH2:2][CH3:1])[C:11]=1[C:12]#[N:13]

참가 물질

반응물 2

HCID 115134-Heptanol

HCID 5226592-Amino-6-fluorobenzonitrile

생성물 1

HCID 667456982-Amino-6-(heptan-4-yloxy)benzonitrile

실험 절차

Prepared as in Example 22b from heptan-4-ol and 2-amino-6-fluorobenzonitrile as a white solid (24%). 1H NR (400 MHz, CDCl3) δ 0.92 (t, J=7.2 Hz, 6H), 1.55-1.31 (m, 8H), 3.88 (s, br, 1H), 4.33-4.27 (m, 1H), 6.26 (d, J=8.0 Hz, 1H), 6.35 (d, J=8.0 Hz, 1H), 7.20 (t, J=8.0 Hz, 1H).

출처 및 근거

ORD 기록: ord-57c3e9d9961347599b1f40de748be876
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09049878B2

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