Sodium Chloride → HCID 90387114, 화합물

HRID 2170229노트

반응식

HRID 2170229 반응식
[O:1]=[C:2]([CH3:14])[CH2:3][C:4](ON1C(=O)CCC1=O)=[O:5].[CH3:15][O:16][C:17]1[CH:30]=[CH:29][C:20]([CH2:21][NH:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])=[CH:19][CH:18]=1.C(N(CC)CC)C.[Cl-].[Na+]>ClCCl>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:21][N:22]([CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[C:4](=[O:5])[CH2:3][C:2](=[O:1])[CH3:14])=[CH:29][CH:30]=1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 5123089N-Hydroxysuccinimidyl acetoacetateHCID 12201326METHYL 3-(4-METHOXYBENZYLAMINO)PROPANOATE

생성물 1

HCID 90387114HCID 90387114, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A flask with stirbar was charged with 2,5-dioxopyrrolidin-1-yl 3-oxobutanoate (6.47 g, 32.5 mmol), methyl 3-(4-methoxybenzylamino)propanoate (prepared as described in Bew, S. et al, Chem Commun. 2006 (41), 4338-40, 7.7 g, 34.5 mmol) and triethylamine (5 mL, 35.9 mmol) in dichloromethane (125 mL). The solution was stirred overnight at ambient temperature, then shaken in a separatory funnel with saturated aqueous sodium chloride. The organics were then washed with saturated aqueous sodium chloride containing 0.1M HCl and dried over anhydrous sodium sulfate. Filtration and solvent removal provided the title compound.

후처리

  1. washThe organics were then washed with saturated aqueous sodium chloride containing 0.1M HCl
  2. dry with materialdried over anhydrous sodium sulfate
  3. filtrationFiltration and solvent removal

출처 및 근거

ORD 기록
ord-29625289c34941ca9a8206d0743ae309
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09050346B2

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