4-Phenoxyphenylboronic acid → N-(1-(6-amino-3-(4-phenoxyphenyl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide

참여 물질

역할	이름	HCID	투입량
반응물	4-Phenoxyphenylboronic acid	HCID 2734377	—
반응물	N-(1-(6-amino-3-bromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide	HCID 90281232	—
반응물	(S)-5-(6-amino-2-(2-(3,5-difluorophenyl)-1-(2-(5-fluoro-1H-indol-3-yl)acetamido)ethyl)pyridin-3-yl)-2-fluorobenzamide	HCID 90281459	—
생성물	N-(1-(6-amino-3-(4-phenoxyphenyl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-fluoro-1H-indol-3-yl)acetamide	HCID 90281307	—

반응 단계

The title compound was prepared according to the method presented for the synthesis of compound 1H of Example 1 utilizing 1G and (4-phenoxyphenyl)boronic acid. 1H NMR (400 MHz, CDCl3) δ 8.03 (s, 1H), 7.65 (d, J=7.8 Hz, 1H), 7.49 (d, J=9.0 Hz, 1H), 7.32 (t, J=7.8 Hz, 2H), 7.29-7.18 (m, 1H), 7.10 (m, 2H), 7.01 (m, 5H), 6.82 (t, J=9.1 Hz, 4H), 6.56 (d, J=8.9 Hz, 1H), 6.43 (s, 1H), 6.19 (d, J=6.4 Hz, 2H), 5.30 (d, J=8.0 Hz, 1H), 3.52 (s, 2H), 2.97-2.85 (m, 1H), 2.75 (dd, J=14.0, 6.9 Hz, 1H). MS (m/z) 592.8 [M+H]+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09050344B2
출처 데이터셋	uspto-grants-2015_06
ORD ID	ord-9b60285759e1470983f76af311b36a93
출처 메모	uspto-grants-2015_06