Triethylamine → (S)-N-(1-(5-bromo-2-(methylamino)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

HRID 2170333노트

반응식

HRID 2170333 반응식
[Br:1][C:2]1[C:3]([C@@H:12]([NH:22][C:23](=[O:41])[CH2:24][N:25]2[C:33]3[C:32]([F:35])([F:34])[CH2:31][CH2:30][C:29]([F:37])([F:36])[C:28]=3[C:27]([CH:38]([F:40])[F:39])=[N:26]2)[CH2:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=2)=[N:4][C:5](S(C)(=O)=O)=[N:6][CH:7]=1.Cl.CN.[CH2:45]([N:47](CC)CC)C>ClCCl>[Br:1][C:2]1[C:3]([C@@H:12]([NH:22][C:23](=[O:41])[CH2:24][N:25]2[C:33]3[C:32]([F:35])([F:34])[CH2:31][CH2:30][C:29]([F:37])([F:36])[C:28]=3[C:27]([CH:38]([F:40])[F:39])=[N:26]2)[CH2:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=2)=[N:4][C:5]([NH:47][CH3:45])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 6364545Methylamine hydrochlorideHCID 90281385(S)-N-(1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

생성물 1

HCID 90281536(S)-N-(1-(5-bromo-2-(methylamino)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the mixture of compound 12C (68 mg, 0.1 mmol) and methylamine hydrochloride (34 mg, 0.5 mmol) in dichloromethane (5 ml) was added triethylamine (697 μL, 0.5 mmol). The reaction mixture was stirring at ambient temperature for 2 hours. The solvent was evaporated and the crude product was purified on reverse phase HPLC eluting with acetonitrile and water (with 0.1% TFA) to afford the title product. MS (m/z) 627.24 [M+H]+.

후처리

  1. customThe solvent was evaporated
  2. customthe crude product was purified on reverse phase HPLC
  3. washeluting with acetonitrile and water (with 0.1% TFA)

출처 및 근거

ORD 기록
ord-23965a81b118492da7b073022a47815c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09050344B2

반응 노트

불러오는 중…