Sodium Bicarbonate → 2-((3bS,4aR)-3-(difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)-N-((S)-2-(3,5-difluorophenyl)-1-(6-(3-hydroxy-3-methylazetidin-1-yl)-3-(1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)ethyl)acetamide

반응식

Br[C:2]1[C:3]([C@@H:14]([NH:24][C:25](=[O:41])[CH2:26][N:27]2[C:31]3[C:32]([F:37])([F:36])[C@@H:33]4[CH2:35][C@@H:34]4[C:30]=3[C:29]([CH:38]([F:40])[F:39])=[N:28]2)[CH2:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=2)=[N:4][C:5]([N:8]2[CH2:11][C:10]([OH:13])([CH3:12])[CH2:9]2)=[CH:6][CH:7]=1.[CH3:42][N:43]1[C:51]2[C:46](=[CH:47][CH:48]=[CH:49][C:50]=2B2OC(C)(C)C(C)(C)O2)[C:45]([NH:61][S:62]([CH3:65])(=[O:64])=[O:63])=[N:44]1.C(=O)(O)[O-].[Na+]>C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.Cl[Pd]Cl.O1CCOCC1>[F:40][CH:38]([F:39])[C:29]1[C:30]2[C@H:34]3[CH2:35][C@H:33]3[C:32]([F:37])([F:36])[C:31]=2[N:27]([CH2:26][C:25]([NH:24][C@H:14]([C:3]2[C:2]([C:50]3[CH:49]=[CH:48][CH:47]=[C:46]4[C:51]=3[N:43]([CH3:42])[N:44]=[C:45]4[NH:61][S:62]([CH3:65])(=[O:64])=[O:63])=[CH:7][CH:6]=[C:5]([N:8]3[CH2:9][C:10]([OH:13])([CH3:12])[CH2:11]3)[N:4]=2)[CH2:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=2)=[O:41])[N:28]=1