[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-methanol → 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde

HRID 217047노트

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HRID 217047 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]([CH2:19][OH:20])=[CH:11][C:12]3[NH:16][CH:15]=[N:14][C:13]=3[C:17]=2[F:18])=[C:4]([Cl:21])[CH:3]=1>O1CCCC1.CC(C)=O.O=[Mn]=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]([CH:19]=[O:20])=[CH:11][C:12]3[NH:16][CH:15]=[N:14][C:13]=3[C:17]=2[F:18])=[C:4]([Cl:21])[CH:3]=1

참가 물질

4

반응물 1

HCID 11428680[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-methanol

생성물 1

HCID 112456086-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde수율 85.2%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 22559816Acetone tetrahydrofuran용매

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온도
50 °C

실험 절차

[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-methanol 10e (0.96 g, 2.58 mmol) is dissolved in tetrahydrofuran/acetone (1:1, 15 mL), and MnO2 (2.24 g, 25.8 mmol) is added. The reaction mixture is stirred at 50° C. for 10 hours under N2. The reaction mixture is filtered through silica gel and eluted with methylene chloride/methanol (10:1, 1 L). The filtrate is concentrated under reduced pressure to a small volume and then filtered through an Acrodisc syringe filter to remove small amounts of MnO2 that passed through the silica gel. The filtrate is concentrated under reduced pressure and the residue is purified by flash column chromatography (eluting with 20:1 methylene chloride:methanol) to yield 0.81 g (85%) of the pure desired product as a bright yellow solid. MS ESI (+) m/z 368, 370 (M+, Br pattern) detected.

후처리

  1. filtrationThe reaction mixture is filtered through silica gel
  2. washeluted with methylene chloride/methanol (10:1, 1 L)
  3. concentrationThe filtrate is concentrated under reduced pressure to a small volume
  4. filtrationfiltered through an Acrodisc syringe
  5. filtrationfilter
  6. customto remove small amounts of MnO2 that
  7. concentrationThe filtrate is concentrated under reduced pressure
  8. customthe residue is purified by flash column chromatography (eluting with 20:1 methylene chloride:methanol)

출처 및 근거

ORD 기록
ord-03e620d52d17493394ec426fb43d3c4b
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193231B2

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