Morpholine → HCID 71075610, 화합물

HRID 2170700노트

반응식

HRID 2170700 반응식
[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=1)[CH2:9][N:10]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([O:21]CC=C)=[O:20])=[CH:16][CH:17]=2)[C:12]([CH3:25])=[C:11]1[CH3:26])([CH3:5])[CH3:4])#[N:2].N1CCOCC1>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=1)[CH2:9][N:10]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([OH:21])=[O:20])=[CH:16][CH:17]=2)[C:12]([CH3:25])=[C:11]1[CH3:26])([CH3:5])[CH3:4])#[N:2]

참가 물질

5

반응물 2

HCID 8083MorpholineHCID 86674589HCID 86674589, 화합물

생성물 1

HCID 71075610HCID 71075610, 화합물

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

The mixture of allyl 1-(3-(2-cyanopropan-2-yl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (0.688 g, 1.78 mmol) and morpholine (1.6 mL, 17.8 mmol) in THF (5 mL) was degassed and then Pd(PPh3)4 (0.21 g, 0.18 mmol) was added. The mixture was stirred at room temperature for 1 h. The solvent was removed and the residue was dissolved in Methanol and acidified to pH4. The solvent was removed and the residue was purified by silica gel to obtain the title compound. ESI-MS (m/z): 347 [M+H]+.

후처리

  1. customwas degassed
  2. customThe solvent was removed
  3. dissolutionthe residue was dissolved in Methanol
  4. customThe solvent was removed
  5. customthe residue was purified by silica gel

출처 및 근거

ORD 기록
ord-44b3877c85414afba2a9b233191fd665
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051265B2

반응 노트

불러오는 중…