Morpholine → HCID 71075333, 화합물

HRID 2170718노트

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HRID 2170718 반응식
[C:1]([C:3]1([C:6]2[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=2)[CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([O:21]CC=C)=[O:20])=[CH:16][CH:17]=3)[C:12]([CH3:25])=[C:11]2[CH3:26])[CH2:5][CH2:4]1)#[N:2].N1CCOCC1>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]([C:3]1([C:6]2[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=2)[CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([OH:21])=[O:20])=[CH:16][CH:17]=3)[C:12]([CH3:25])=[C:11]2[CH3:26])[CH2:4][CH2:5]1)#[N:2]

참가 물질

5

반응물 2

HCID 8083MorpholineHCID 86674597HCID 86674597, 화합물

생성물 1

HCID 71075333HCID 71075333, 화합물

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

The mixture of allyl 1-(3-(1-cyanocyclopropyl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (375 mg, 0.98 mmol) and morpholine (0.8 mL, 9.2 mmol) in THF (8 mL) was degassed and then Pd(PPh3)4 (117 mg, 0.10 mmol) was added. The mixture was stirred at room temperature for 1 h. The solvent was removed and the residue was dissolved in Methanol and acidified to pH 4. The precipitate was collected and washed with water to obtain the title compound.

후처리

  1. customwas degassed
  2. customThe solvent was removed
  3. dissolutionthe residue was dissolved in Methanol
  4. customThe precipitate was collected
  5. washwashed with water

출처 및 근거

ORD 기록
ord-8b5f423b20cb43888807304be023fde7
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051265B2

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