참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamidine acetate | HCID 160693 | — |
| 반응물 | 4,5-Diamino-3-chloro-2-phenylamino-benzoic acid methyl ester | HCID 85868198 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 7-Chloro-6-phenylamino-3H-benzoimidazole-5-carboxylic acid methyl ester | HCID 86599017 | 100.3% |
반응 단계
4,5-Diamino-3-chloro-2-phenylamino-benzoic acid methyl ester 6b (0.32 g, 1.09 mmol) and formamidine acetate (72 mg, 1.64 mmol) in EtOH (36 mL) are heated, with stirring, to 80° C. After 44 hours, the reaction mixture is cooled to room temperature and diluted with EtOAc and washed with water (3×), saturated NaHCO3, and brine. The combined organic extracts are dried (Na2SO4) and concentrated under reduced pressure to give 0.33 g (99%) clean desired product as a solid. MS APCI (+) m/z 302.3 (M+1) detected.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08193231B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-fd180e6ad3f14268a56a746c12f13f12 |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
