Triethylamine → HCID 54577374, 화합물

HRID 2171027노트

반응식

HRID 2171027 반응식
[NH2:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:13]([O:14][CH3:15])=[C:12]([O:16][CH3:17])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[CH2:5][CH2:4]1.C(N(CC)CC)C.[C:35](Cl)(=[O:39])[O:36][CH2:37][CH3:38].C(OCC)(=O)C>ClCCl>[CH2:37]([O:36][C:35](=[O:39])[NH:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:9]([C:18]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:19]=3[CH2:20][CH2:21][C:22]4=[O:27])=[CH:10][CH:11]=[C:12]([O:16][CH3:17])[C:13]=2[O:14][CH3:15])[CH2:4][CH2:5]1)[CH3:38]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 10928Ethyl chloroformateHCID 71279377HCID 71279377, 화합물2회

생성물 1

HCID 54577374HCID 54577374, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirring solution of 4-[2-(1-Aminomethyl-cyclopropylmethoxy)-3,4-dimethoxy-phenyl]-indan-1-one (Compound 182) (110 mg, 0.272 mmol) in dichloromethane (10 mL), were added triethylamine (0.082 g, 0.811 mmol) and ethyl carbonochloridate (59 mg, 0.544 mmol) and the resultant reaction mixture was subjected to the conditions used in the preparation of Compound 183 and Purification by column chromatography (silica gel, 0-25% ethyl acetate in pet ether) to afford the title compound as a solid.

후처리

  1. customthe resultant reaction mixture

출처 및 근거

ORD 기록
ord-74d6f9834a694110b1553e726c3b72e4
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051290B2

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