참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Risedronate | HCID 5245 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Risedronate sodium hemi-pentahydrate | HCID 11954322 | 194.1% |
반응 단계
To 60 ml of purified water, 10.0 g of 2-(3-pyridyl)-1-hydroxyethane-1,1-bisphosphonic acid (risedronic acid) and 1.41 g of sodium hydroxide were added and dissolved at an elevated temperature of 65° C. After the dissolution, the resulting solution was cooled to 25° C. over 3 hours for crystallization. The obtained crystals were filtered and vacuum dried to obtain 8.0 g of risedronate sodium hemipentahydrate (64.7% of theoretical yield). (LOD by TGA=13.2%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08193355B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-9e6beb172792440a92180700437b9fb4 |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
