Triethylamine → HCID 86728321, 화합물
반응식
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.C(N(CC)CC)C.[CH3:17][NH:18][C@@H:19]([CH3:22])[CH2:20][OH:21]>C(#N)C.CN(C)C=O>[Cl:1][C:2]1[N:3]=[C:4]([N:18]([CH3:17])[C@@H:19]([CH3:22])[CH2:20][OH:21])[CH:5]=[C:6]([Cl:8])[N:7]=1참가 물질
6
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 2,4,6-trichloropyrimidine (5.42 mL, 47.1 mmol) and triethylamine (19.7 mL, 141 mmol) in acetonitrile (40 mL) was slowly added (S)-2-(methylamino)propan-1-ol (6.30 g, 70.7 mmol) in N,N-dimethylformamide (DMF) (3.00 mL) at 0° C. The reaction mixture was stirred at 0° C. for 1 h, filtered, dried over anhydrous Na2SO4, concentrated. Purification via flash chromatography column (petroleum ether/ethyl acetate=10/1) afforded the title product.
후처리
- customat 0° C
- filtrationfiltered
- dry with materialdried over anhydrous Na2SO4
- concentrationconcentrated
- customPurification via flash chromatography column (petroleum ether/ethyl acetate=10/1)
출처 및 근거
- ORD 기록
- ord-3f31fb1885584717ab274326df30db03
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09051325B2
반응 노트
불러오는 중…