Potassium Hydroxide → HCID 178517804, 화합물

HRID 2171503노트

반응식

HRID 2171503 반응식
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1.[OH-:13].[K+]>CO>[Cl:1][C:2]1[N:7]=[C:6]([OH:13])[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 592990517-Chloro-5-methylsulfanyl-[1,2,4]triazolo[1,5-c]pyrimidine

생성물 1

HCID 178517804HCID 178517804, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2.58 g (12.9 mmol) of 7-chloro-5-(methylthio)[1,2,4]triazolo[1,5-c]pyrimidine (Example 51A) is dissolved in 300 ml of methanol, and 28 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is heated under reflux for 3 h. After the reaction is complete, the methanol is removed in vacuo, the mixture is neutralized with half-concentrated hydrochloric acid, and the crystals which have separated out are filtered off with suction. They are washed with water and methanol and then dried under high vacuum. 1.82 g (83% of theory) of the product are obtained.

후처리

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 h
  3. customthe methanol is removed in vacuo
  4. customthe crystals which have separated out
  5. filtrationare filtered off with suction
  6. washThey are washed with water and methanol
  7. customdried under high vacuum
  8. custom1.82 g (83% of theory) of the product are obtained

출처 및 근거

ORD 기록
ord-8c3161226766429eafe48725d59d04ad
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051323B2

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