Ethyl bromopyruvate → HCID 59313149, 화합물

HRID 2171510노트

반응식

HRID 2171510 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][CH2:11][NH:12][C:13]2[N:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=2)[N:3]=1.Br[CH2:22][C:23](=O)[C:24]([O:26][CH2:27][CH3:28])=[O:25]>CN(C=O)C>[Cl:8][C:6]1[N:5]=[C:4]([NH:9][CH2:10][CH2:11][NH:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]#[N:20])=[CH:17][N:18]=2)[N:3]2[CH:22]=[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[N:1]=[C:2]2[CH:7]=1

참가 물질

4

반응물 2

HCID 66144Ethyl bromopyruvateHCID 59313150HCID 59313150, 화합물

생성물 1

HCID 59313149HCID 59313149, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

480 mg (1.66 mmol) of 6-({2-[(4-amino-6-chloropyrimidin-2-yl)amino]ethyl}amino)pyridine-3-carbonitrile and 538 mg (2.49 mmol) of ethyl bromopyruvate are dissolved in 8 ml of DMF and heated at 100° C. for 16 h. After the reaction is complete, the crude mixture is purified by preparative HPLC. 190 mg (27% of theory) of the product are obtained as a solid.

후처리

  1. customthe crude mixture is purified by preparative HPLC
  2. custom190 mg (27% of theory) of the product are obtained as a solid

출처 및 근거

ORD 기록
ord-629dc68395df4169953dcdb0728f75ad
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051323B2

반응 노트

불러오는 중…