Potassium Carbonate → HCID 86709374, 화합물

HRID 2172191노트

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HRID 2172191 반응식
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[OH:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([CH:28]=O)=[CH:24][CH:23]=2)=[CH:18][CH:17]=1.[F:30][C:31]([F:47])([F:46])[O:32][C:33]1[CH:45]=[CH:44][C:36]([O:37][CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:35][CH:34]=1.C(=O)([O-])[O-].[K+].[K+]>ClCCCl>[F:47][C:31]([F:30])([F:46])[O:32][C:33]1[CH:45]=[CH:44][C:36]([O:37][CH:38]2[CH2:39][CH2:40][N:41]([CH2:28][C:25]3[CH:24]=[CH:23][C:22]([C:19]4[CH:18]=[CH:17][C:16]([OH:15])=[CH:21][CH:20]=4)=[CH:27][CH:26]=3)[CH2:42][CH2:43]2)=[CH:35][CH:34]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 27592994-(4-hydroxyphenyl)benzaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 161154394-[4-(Trifluoromethoxy)phenoxy]piperidine

생성물 1

HCID 86709374HCID 86709374, 화합물수율 68.4%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Sodium triacetoxyborohydride (1.69 g) was added to a 1,2-dichloroethane solution (11 ml) of 4′-hydroxybiphenyl-4-carbaldehyde (1.13 g) and 4-(4-trifluoromethoxyphenoxy)piperidine (1.78 g) and stirred at room temperature overnight. A potassium carbonate aqueous solution was added to the reaction mixture, followed by extraction with dichloromethane. The organic layer was washed with water, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:0→0:10) to afford the title compound as a yellow powder (1.73 g).

후처리

  1. extractionfollowed by extraction with dichloromethane
  2. washThe organic layer was washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:0→0:10)

출처 및 근거

ORD 기록
ord-4142d366029a4c22b1943b3f75290232
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051333B2

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