Triethylamine → 2-Carbamyl-6-Hydroxybenzothiazole Dimethylphosphate

HRID 21722

반응식

HRID 21722 반응식
[C:1]([C:4]1[S:5][C:6]2[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:7]=2[N:8]=1)(=[O:3])[NH2:2].C(N(CC)CC)C.[CH3:21][O:22][P:23](Cl)([O:25]C)=[O:24]>C1COCC1>[CH3:21][O:22][P:23]([OH:25])([O:13][CH3:11])=[O:24].[C:1]([C:4]1[S:5][C:6]2[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:7]=2[N:8]=1)(=[O:3])[NH2:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 101863Phosphorochloridic acid, dimethyl esterHCID 98389112-Benzothiazolecarboxamide, 6-hydroxy-

생성물 1

HCID 867487322-Carbamyl-6-Hydroxybenzothiazole Dimethylphosphate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Three grams (0.015moles) of 2-carbamyl-6-hydroxybenzothiazole (ABT) was dissolved in 30 mLs of THF. Then 1.72 g (0.017 moles) triethylamine was added to the stirring reaction solution, followed immediately by the addition over 5 minutes of 2.6 g (0.018 moles) of dimethylchlorophosphate dissolved in 7 mLs of THF. This solution was stirred for 72 hours at room temperature.

출처 및 근거

ORD 기록
ord-34a06c3811de450caff1736c91de2d1f
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424440

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