Delta-Valerolactone → Pentanoic acid, 5-hydroxy-, methyl ester
반응식
[CH3:1][O-:2].[Na+].[O:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[O:10]>CO>[CH3:1][O:2][C:9](=[O:4])[CH2:8][CH2:7][CH2:6][CH2:5][OH:10]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of sodium methoxide (71.3 mg, 1.32 mmol) in anhydrous MeOH (4 ml), tetrahydro-pyran-2-one (1.32 g, 13.2 mmol) is added dropwise at room temperature under nitrogen. The mixture is stirred at 50° C. for 4 hours and filtered through a silica gel short column (eluent: diethyl ether). Collected filtrate is concentrated under reduced pressure to give 5-hydroxy-pentanoic acid methyl ester; 1H NMR (400 MHz, chloroform-d) ppm 1.57-1.76 (m, 4H), 2.35 (m, 2H), 3.65 (m, 5H).
후처리
- filtrationfiltered through a silica gel short column (eluent: diethyl ether)
- concentrationCollected filtrate is concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-4f67e378ad1149a29304e130c34d5861
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08193349B2
반응 노트
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