Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4,5,6-Tetrahydrophthalic anhydride → N-(2,4-Dichloro-6-fluorobenzothiazol-7-yl)-3,4,5,6-tetrahydrophthalimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4,5,6-Tetrahydrophthalic anhydride | HCID 12475 | — |
| 반응물 | 7-Amino-2,4-dichloro-6-fluorobenzothiazole | HCID 19933457 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | N-(2,4-Dichloro-6-fluorobenzothiazol-7-yl)-3,4,5,6-tetrahydrophthalimide | HCID 19933466 | — |
반응 단계
A solution of 6 g 7-amino-2,4-dichloro-6-fluoro-benzothiazole and 4.3 g 3,4,5,6-tetrahydrophthalic anhydride in 50 ml acetic acid was heated under reflux for 5 hours. After cooling, the reaction solution was poured into 200 ml ice-water and the resulting crystals were separated off. They were dried at 50° C. in vacuo and then purified by column chromatography. Yield: 6.6 g=70% of theory m.p.: 139°-141° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424443 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-a7ad4b452cd840e4b80e1f788cd0e5ae |
| 출처 메모 | uspto-grants-1995_06 |