5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride → 5-(2-(1H-Imidazol-1-yl)-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

HRID 2172316노트

반응식

HRID 2172316 반응식
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([S:12]([NH:15][C:16]1[S:17][C:18]([F:21])=[CH:19][N:20]=1)(=[O:14])=[O:13])[CH2:7]2.[N:22]1([C:27]2[CH:32]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:30]=[CH:29][C:28]=2C2C=CC=C3C=2CNCC3)[CH:26]=[CH:25][N:24]=[CH:23]1.Cl.BrC1C=CC=C2C=1CCNC2>>[N:22]1([C:27]2[CH:32]=[C:31]([C:33]([F:34])([F:35])[F:36])[CH:30]=[CH:29][C:28]=2[C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH2:4][CH2:5][N:6]([S:12]([NH:15][C:16]2[S:17][C:18]([F:21])=[CH:19][N:20]=2)(=[O:14])=[O:13])[CH2:7]3)[CH:26]=[CH:25][N:24]=[CH:23]1

참가 물질

4

반응물 3

HCID 450740035-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 898151228-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline2회HCID 898155775-bromo-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

생성물 1

HCID 717367385-(2-(1H-Imidazol-1-yl)-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

실험 절차

The title compound was prepared in a procedure analogous to Intermediate I, wherein 8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (Intermediate R) was substituted for 5-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride [M+H]+=524.0 1H NMR (400 MHZ, Acetone-d6) δ ppm: 7.97 (s, 1H), 7.91 (dd, J=7.9, 1.0 Hz, 1H), 7.70 (d, J=8.0 Hz, 1H), 7.48 (d, J=1.0 Hz, 1H), 7.44 (t, J=1.3 Hz, 1H), 7.10-7.19 (m, 2H), 6.97-7.02 (m, 3H), 4.28-4.41 (m, 2H), 3.68-3.77 (m, 1H), 3.21-3.32 (m, 1H), 2.44-2.54 (m, 2H)

출처 및 근거

ORD 기록
ord-085b2786236d410680b937bea9f7b26d
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051311B2

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