Trifluoroacetic acid → 5-Chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

HRID 2172589노트

반응식

HRID 2172589 반응식
[Cl:1][C:2]1[C:3](=[O:36])[N:4]([C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]([OH:34])([CH3:33])[CH3:32])[N:26]=3)[CH:22]=[CH:21][C:20]=2[CH3:35])[C:5]([CH3:18])=[N:6][C:7]=1[O:8]CC1C=CC(OC)=CC=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:3](=[O:36])[N:4]([C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]([OH:34])([CH3:32])[CH3:33])[N:26]=3)[CH:22]=[CH:21][C:20]=2[CH3:35])[C:5]([CH3:18])=[N:6][C:7]=1[OH:8]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 866862845-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one

생성물 1

HCID 1363878065-Chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution 5-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one from Step I (661 mg, 1.31 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (1 mL). The solution was stirred at ambient temperature for one hour. Concentration in vacuo provided the title compound as a yellow solid (assume theoretical yield). MS (M+H): 387

후처리

  1. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-0ddde50e769a4f06b743f927d14a6100
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056110B2

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