N-Allyl-2,2,2-trifluoroacetamide → (E)-2,2,2-trifluoro-N-(3-(3-(2-(1-hydroxycyclohexyl)ethyl)phenyl)allyl)acetamide

반응식

Br[C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][CH2:6][C:7]1([OH:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[CH2:17]([NH:20][C:21](=[O:26])[C:22]([F:25])([F:24])[F:23])[CH:18]=[CH2:19]>>[F:23][C:22]([F:25])([F:24])[C:21]([NH:20][CH2:17]/[CH:18]=[CH:19]/[C:2]1[CH:16]=[CH:15][CH:14]=[C:4]([CH2:5][CH2:6][C:7]2([OH:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:3]=1)=[O:26]

참가 물질

반응물 2

HCID 558569N-Allyl-2,2,2-trifluoroacetamide

HCID 57956767HCID 57956767, 화합물

생성물 1

HCID 57956840(E)-2,2,2-trifluoro-N-(3-(3-(2-(1-hydroxycyclohexyl)ethyl)phenyl)allyl)acetamide

실험 절차

Coupling of 1-(3-bromophenethyl)cyclohexanol with N-allyl-2,2,2-trifluoroacetamide following the method described in Example 118 gives (E)-2,2,2-trifluoro-N-(3-(3-(2-(1-hydroxycyclohexyl)ethyl)phenyl)allyl)acetamide.

출처 및 근거

ORD 기록: ord-aa2d7217557e4f00aea101240033dad2
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09056849B2

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