Bromine → 3-Bromo-6-methoxy-2-methylbenzonitrile

HRID 2173221노트

반응식

HRID 2173221 반응식
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:6]=1[C:7]#[N:8]>C(Cl)(Cl)(Cl)Cl.[Fe]>[Br:1][C:10]1[C:9]([CH3:13])=[C:6]([C:5]([O:4][CH3:3])=[CH:12][CH:11]=1)[C:7]#[N:8]

참가 물질

5

반응물 2

HCID 24408BromineHCID 5902262-Methoxy-6-methylbenzonitrile

생성물 1

HCID 675160643-Bromo-6-methoxy-2-methylbenzonitrile

시약·촉매·용매 2

HCID 23925Iron촉매HCID 5943Carbon Tetrachloride용매2회

실험 절차

A solution of Br2 (261 mg, 1.63 mmol) in CCl4 (1 mL) was added over 15 min to a solution of 2-methoxy-6-methylbenzonitrile in CCl4 (3 mL) at −10° C. containing 4 mg of Fe powder. After 45 min the reaction was poured into ice water (10 mL). The organic layer was washed with Na2SO3 (aq.) solution (10 mL*2), brine (20 mL) and dried over Na2SO4, concentrated in vacuo to give 3-bromo-6-methoxy-2-methylbenzonitrile.

후처리

  1. washThe organic layer was washed with Na2SO3 (aq.) solution (10 mL*2), brine (20 mL)
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-56803d2b069049ea98f67b2c651480d3
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056859B2

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