Diisobutylaluminum hydride → 2-Fluoro-5-(1-oxopropan-2-yl)benzonitrile
반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]([CH3:15])[C:11](OC)=[O:12])[CH:6]=[CH:7][C:8]=1[F:9])#[N:2].CC(C[AlH]CC(C)C)C>C1COCC1>[F:9][C:8]1[CH:7]=[CH:6][C:5]([CH:10]([CH3:15])[CH:11]=[O:12])=[CH:4][C:3]=1[C:1]#[N:2]참가 물질
4
실험 절차
A solution of compound methyl 2-(3-cyano-4-fluorophenyl)propanoate (50 mg, 0.24 mmol) in 5 mL of anhydrous THF was cooled to 0° C. and then added DIBAL-H (0.3 mmol) was added. The mixture was warmed to ambient temperature and stirred at ambient temperature for 1.5 hours. The reaction was quenched with water, extracte with EtOAc. The organic layer was washed with saturated chloride, dried over anhydrous sodium sulfate and concentrated. The 2-fluoro-5-(1-oxopropan-2-yl)benzonitrile was used for next step without purification.
후처리
- customThe reaction was quenched with water, extracte with EtOAc
- washThe organic layer was washed with saturated chloride
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
- customThe 2-fluoro-5-(1-oxopropan-2-yl)benzonitrile was used for next step without purification
출처 및 근거
- ORD 기록
- ord-88859a80a4bb42f8941660852d579e1d
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09056859B2
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