tert-Butyl piperazine-1-carboxylate → 5-(Piperazin-1-ylmethyl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile
반응식
[CH:1]([CH:3]1[CH2:12][CH2:11][CH2:10][C:9]2[C:8]([C:13]#[N:14])=[CH:7][CH:6]=[CH:5][C:4]1=2)=O.[N:15]1(C(OC(C)(C)C)=O)[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.COC1C=C(CCN2CCNCC2)C=CC=1C#N>>[N:15]1([CH2:1][CH:3]2[CH2:12][CH2:11][CH2:10][C:9]3[C:8]([C:13]#[N:14])=[CH:7][CH:6]=[CH:5][C:4]2=3)[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1참가 물질
4
실험 절차
5-(Piperazin-1-ylmethyl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile was prepared starting from 5-formyl-5,6,7,8-tetrahydronaphthalene-1-carbonitrile and tert-butyl piperazine-1-carboxylate in two steps in an analogous fashion to that described for the synthesis of 2-methoxy-4-[2-(piperazin-1-yl)ethyl]benzonitrile above.
출처 및 근거
- ORD 기록
- ord-4096ed8f59bd416f87bef846bb2efa17
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09056859B2
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