Tert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate → Ethyl 2-(5-nitropyrazin-2-yl)acetate

HRID 2173328노트

반응식

HRID 2173328 반응식
[N+:1]([C:4]1[N:5]=[CH:6][C:7]([CH:10](C(OCC)=O)[C:11]([O:13][C:14](C)(C)[CH3:15])=[O:12])=[N:8][CH:9]=1)([O-:3])=[O:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N+:1]([C:4]1[N:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:8][CH:9]=1)([O-:3])=[O:2]

참가 물질

4

반응물 1

HCID 86693017Tert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate

생성물 1

HCID 77230650Ethyl 2-(5-nitropyrazin-2-yl)acetate

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

반응 조건

온도
35 °C

실험 절차

A mixture of tert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate (10.7 g, 34.4 mmol) in 30 mL of TFA and 30 mL DCM was stirred at 35° C. for 3 hours before concentrated to dryness. The residue was dissolved in 200 mL of EtOAc and washed with water (25 mL) and brine (25 mL), dried over anhydrous Na2SO4 and concentrated to afford ethyl (5-nitropyrazin-2-yl)acetate.

후처리

  1. concentrationbefore concentrated to dryness
  2. dissolutionThe residue was dissolved in 200 mL of EtOAc
  3. washwashed with water (25 mL) and brine (25 mL)
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3e5d3563466f481f81fe9520e2bfde19
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056859B2

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