2-(3-fluoro-4-nitrophenyl)acetic acid → 4-Amino-3-fluorophenylacetic acid

HRID 2173385노트

반응식

HRID 2173385 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>CCOC(C)=O.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH2:11][C:12]([OH:14])=[O:13])=[CH:3][C:2]=1[F:1]

참가 물질

4

반응물 1

HCID 27746652-(3-fluoro-4-nitrophenyl)acetic acid

생성물 1

HCID 27783244-Amino-3-fluorophenylacetic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of (3-fluoro-4-nitrophenyl)acetic acid (1 g, 5 mmol) in 30 mL of EtOAc was added 180 mg of Pd/C was stirred at room temperature under H2 atmosphere overnight. The reaction mixture was filtrated and concentrated to give (4-amino-3-fluorophenyl)acetic acid.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cc367f5c70864bcca07db82522367cec
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056859B2

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