Di-tert-butyl malonate → 2-(3-Bromo-4-cyanophenyl)acetic acid

HRID 2173410노트

반응식

HRID 2173410 반응식
[C:1]([C:3]1[C:8](OC)=[CH:7][C:6]([CH2:11][C:12]([OH:14])=[O:13])=[C:5](F)[CH:4]=1)#[N:2].C(OC(C)(C)C)(=O)CC(OC(C)(C)C)=O.[Br:31]C1C=C(C=CC=1F)C#N>>[Br:31][C:8]1[CH:7]=[C:6]([CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:4][C:3]=1[C:1]#[N:2]

참가 물질

4

반응물 3

HCID 68324Di-tert-butyl malonateHCID 1235793-Bromo-4-fluorobenzonitrileHCID 665248932-(4-Cyano-2-fluoro-5-methoxyphenyl)acetic acid

생성물 1

HCID 665249442-(3-Bromo-4-cyanophenyl)acetic acid

실험 절차

(3-Bromo-4-cyanophenyl)acetic acid was prepared in a similar fashion to the previously described synthesis of (4-cyano-2-fluoro-5-methoxyphenyl)acetic acid starting from di-tert-butyl malonate and 3-bromo-4-fluorobenzonitrile. LC-MS (IE, m/z): 239, 241 [M+1]+.

출처 및 근거

ORD 기록
ord-5fd43457cade47479403a33dd6b11272
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056859B2

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