(3S)-6-bromo-3-methyl-3,4-dihydro-1H-isochromen-1-one → (3S)-3-methyl-6-[2-(piperazin-1-yl)ethyl]-3,4-dihydro-1H-isochromen-1-one hydrochloride

HRID 2173421노트

반응식

HRID 2173421 반응식
[ClH:1].[CH3:2][C@@H:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[CH:10]=2)[C:5](=[O:21])[O:4]1.BrC1C=C2C(=CC=1)C(=O)O[C@@H](C)C2>>[ClH:1].[CH3:2][C@H:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[CH:10]=2)[C:5](=[O:21])[O:4]1

참가 물질

3

반응물 2

HCID 67517728(3S)-6-bromo-3-methyl-3,4-dihydro-1H-isochromen-1-oneHCID 86693037(3R)-3-methyl-6-[2-(piperazin-1-yl)ethyl]-3,4-dihydro-1H-isochromen-1-one hydrochloride

생성물 1

HCID 86693036(3S)-3-methyl-6-[2-(piperazin-1-yl)ethyl]-3,4-dihydro-1H-isochromen-1-one hydrochloride

실험 절차

(3S)-3-methyl-6-[2-(piperazin-1-yl)ethyl]-3,4-dihydro-1H-isochromen-1-one hydrochloride was prepared in a similar manner as (3R)-3-methyl-6-[2-(piperazin-1-yl)ethyl]-3,4-dihydro-1H-isochromen-1-one hydrochloride except starting from (3S)-6-bromo-3-methyl-3,4-dihydro-1H-isochromen-1-one.

출처 및 근거

ORD 기록
ord-1b71af7ffcca459ea7d7632306cda0c0
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056859B2

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