Chloroacetonitrile → HCID 117729502, 화합물

HRID 2173472노트

반응식

HRID 2173472 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[N:6][NH:5][C:4](=[S:9])[C:3]=1[C:10]#[N:11].C([O-])(=O)C.[Na+].Cl[CH2:18][C:19]#[N:20]>C(O)C.CC(O)C>[NH2:11][C:10]1[C:3]2[C:2]([CH3:1])=[C:7]([CH3:8])[N:6]=[N:5][C:4]=2[S:9][C:18]=1[C:19]#[N:20]

참가 물질

6

반응물 3

HCID 7856ChloroacetonitrileHCID 517045Sodium AcetateHCID 256489772,3-Dihydro-5,6-dimethyl-3-thioxo-4-pyridazinecarbonitrile

생성물 1

HCID 117729502HCID 117729502, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3776Isopropanol용매

실험 절차

The 5,6,-dimethyl-3-thioxo-2,3-dihydropyridazine-4-carbonitrile (99 mg, 0.60 mmol) was stirred in ethanol (6.0 mL). Sodium acetate (50 mg, 0.60 mmol) and chloroacetonitrile (0.040 mL, 0.60 mmol) were added and the mixture was stirred at ambient temperature for 90 minutes. The mixture was then diluted with IPA, stirred for 15 minutes, and filtered. The solute was concentrated in vacuo, and the resulting solid was dried overnight at 60° C. in a vacuum oven to give the product. LC/MS: RT=0.38 min., m/z=205 [M+H]+.

후처리

  1. stirringstirred for 15 minutes
  2. filtrationfiltered
  3. concentrationThe solute was concentrated in vacuo
  4. customthe resulting solid was dried overnight at 60° C. in a vacuum oven
  5. customto give the product

출처 및 근거

ORD 기록
ord-bcb2fbd5ca604b6381446071b81a4b68
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056875B2

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