5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → 5-tert-Butyl-3-(2-chloro-benzyl)-7-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

HRID 2173511

반응식

HRID 2173511 반응식
[C:1]([C:5]1[N:6]=[C:7]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:28](C1N=C(Cl)C2N=NN(CC3C=CC=CC=3Cl)C=2N=1)(C)(C)C.C(O)(=O)C(O)=O.N1C2(COC2)CC1>>[C:1]([C:5]1[N:6]=[C:7]([N:22]2[C:23]3([CH2:28][O:25][CH2:24]3)[CH2:26][CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:9]=2[N:10]=1)([CH3:3])([CH3:4])[CH3:2]

참가 물질

4

반응물 3

HCID 14339535-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 713039926-Oxa-1-azaspiro[3.3]heptane oxalateHCID 866832845-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

생성물 1

HCID 715577225-tert-Butyl-3-(2-chloro-benzyl)-7-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

실험 절차

In analogy to the procedure described for the synthesis of 5-tert-butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 6-oxa-1-azaspiro[3.3]heptane oxalate and isolated as light-yellow gum (12.5 mg, 65%). MS(m/e): 399.4 (MH+).

출처 및 근거

ORD 기록
ord-bb5a15125035460b8d4cdc81ed961f2e
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056866B2

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