Potassium tert-butoxide → HCID 178441781, 화합물

HRID 2173628노트

반응식

HRID 2173628 반응식
[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]([CH2:20][OH:21])([CH2:18]Cl)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]3([CH2:20][O:21][CH2:18]3)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 23665647Potassium tert-butoxideHCID 178441793HCID 178441793, 화합물

생성물 1

HCID 178441781HCID 178441781, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of (1-(5-tert-butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-3-(chloromethyl)azetidin-3-yl)methanol (284 mg, 915 μmol) (example 179, step 2) and potassium tert-butoxide (205 mg, 1.83 mmol) in THF (3 mL) at 0° C. was stirred to room temperature and stirred for 20 h. The mixture was filtered, concentrated in vacuo and used without further purification in the consecutive step.

후처리

  1. stirringstirred for 20 h
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated in vacuo
  4. customused without further purification in the consecutive step

출처 및 근거

ORD 기록
ord-d5de93f52aa5419b88f28cd839f3dffe
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056866B2

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