Triethylamine → (+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone
반응식
[C:1]([N:4]1[CH2:8][C@H:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2].C(N(CC)CC)C.S1C=CC=C1CC(O)=O>C(OCC)(=O)C>[C:1]([N:4]1[CH2:8][CH:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2]참가 물질
5
실험 절차
(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).
후처리
- temperaturethe mixture is refluxed for three hours
- washThe reaction solution is washed with water
- customdried
- customevaporated
- customto remove the solvent
출처 및 근거
- ORD 기록
- ord-78b65f57d4cc4543959bfb9496b3572a
- 출처 데이터셋
- uspto-grants-1995_06
- 특허 번호
- US05424446
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