Triethylamine → (+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone

HRID 21737

반응식

HRID 21737 반응식
[C:1]([N:4]1[CH2:8][C@H:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2].C(N(CC)CC)C.S1C=CC=C1CC(O)=O>C(OCC)(=O)C>[C:1]([N:4]1[CH2:8][CH:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 159702-Thiopheneacetic acidHCID 86748734(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone

생성물 1

HCID 86748735(+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone수율 90%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).

후처리

  1. temperaturethe mixture is refluxed for three hours
  2. washThe reaction solution is washed with water
  3. customdried
  4. customevaporated
  5. customto remove the solvent

출처 및 근거

ORD 기록
ord-78b65f57d4cc4543959bfb9496b3572a
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424446

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