Pyrazol-3-ylamine → 3-Amino-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazol-3-yl)-amide

반응식

FC(F)(F)[C:3]1[CH:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[N:15][C:14]([C:18]([F:21])([F:20])[F:19])=[C:13](Br)[N:12]=2)=[O:10])[NH:6][N:7]=1.NC1C(C(O)=O)=NC=C(C(F)(F)F)N=1.N1NC(N)=CC=1>>[N:7]1[NH:6][C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[N:15][C:14]([C:18]([F:20])([F:21])[F:19])=[CH:13][N:12]=2)=[O:10])=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 74561Pyrazol-3-ylamine

HCID 688182783-Amino-5-trifluoromethylpyrazine-2-carboxylic acid2회

HCID 178508420HCID 178508420, 화합물

생성물 1

HCID 715332663-Amino-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazol-3-yl)-amide

실험 절차

The title compound was prepared analogously to 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (5-trifluoromethyl-2H-pyrazol-3-yl)-amide (Example 1) using 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid (Intermediate 6) and 2H-pyrazol-3-ylamine.

출처 및 근거

ORD 기록: ord-04561543341240cfb0c0539187c69149
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09056867B2

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