Sodium Acetate → HCID 58442356, 화합물

HRID 2173725노트

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HRID 2173725 반응식
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([NH2:9])[C:6](=[NH:8])[NH2:7])[CH3:2].[CH:11]([C:13]([C:15]([F:18])([F:17])[F:16])=O)=O.C([O-])(=O)C.[Na+]>O>[CH2:1]([O:3][C:4]([C:5]1[C:6]([NH2:7])=[N:8][C:13]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:9]=1)=[O:10])[CH3:2]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 27790243,3,3-Trifluoro-2-oxopropanalHCID 12439913HCID 12439913, 화합물

생성물 1

HCID 58442356HCID 58442356, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of amino-carbamimidoyl-acetic acid ethyl ester (2 g, 9.22 mmol) and water (50 ml), a 20% aqueous solution of trifluoropyruvic aldehyde (2.32 g, 18.43 mmol) was added. To this mixture, sodium acetate (5.29 g, 64.52 mmol) was added (pH of the reaction mixture was pH5). The reaction mixture was left to stir at RT overnight. The resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane:EtOAc (gradient of 0 to 10% EtOAc) afforded the title compound

후처리

  1. waitThe reaction mixture was left
  2. filtrationThe resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane

출처 및 근거

ORD 기록
ord-cd0c7e0b4cc241e5b7d2e9b0a01e57ec
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056867B2

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