Sodium Carbonate → Ethyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate

HRID 2173727노트

반응식

HRID 2173727 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH2:12])=[N:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)=[O:5])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].[Br:23]Br>C(O)(=O)C.O>[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH2:12])=[N:10][C:9]([C:13]([F:15])([F:16])[F:14])=[C:8]([Br:23])[N:7]=1)=[O:5])[CH3:2]

참가 물질

6

반응물 3

HCID 10340Sodium Carbonate2회HCID 24408Bromine2회HCID 58442356HCID 58442356, 화합물2회

생성물 1

HCID 72942096Ethyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate

시약·촉매·용매 2

HCID 176Acetic Acid용매3회HCID 962Water용매

실험 절차

To a solution of 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate 1) (30 mg, 0.13 mmol) in acetic acid (5 ml), sodium carbonate (15 mg, 0.14 mmol) was added. To this mixture, half the contents of a solution of bromine (7 μL, 0.13 mmol) in acetic acid (5 ml) was added, followed by the addition of sodium carbonate ((15 mg, 0.14 mmol). The remaining solution of bromine in acetic acid was added and the reaction mixture was left to stir at RT for 2 hours. The mixture was diluted with water and the resulting yellow precipitate was filtered under vacuum to afford the title compound.

후처리

  1. waitthe reaction mixture was left
  2. filtrationthe resulting yellow precipitate was filtered under vacuum

출처 및 근거

ORD 기록
ord-050f49e1e44746e89208b7136c99d9ca
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056867B2

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