Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Nicardipine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Nicardipine Hydrochloride | HCID 41114 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Nicardipine | HCID 4474 | — |
반응 단계
Nicardipine (free base) was prepared by mixing nicardipine-HCl (Sigma-Aldrich, St. Louis, USA) with water and ethylacetate, then adding 2M NaOH, separating the ethylacetate phase and evaporating the ethylacetate, yielding amorphous nicardipine base as a yellow oily-tough substance. Crystalline nicardipine base was prepared by mixing amorphous nicardipine base and isopropanole/diisopropyl ether, adding seed crystals and cooling on an ice bath over night to allow crystallization. The formed crystals were separated by filtration, washed and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09060986B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-1777db7c9d7c49ecbf704d757e181d1a |
| 출처 메모 | uspto-grants-2015_06 |