Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 217446생성일: 2026년 10월 25일
[(4-Isobutylphenyl)ethynyl](trimethyl)silane → 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde
https://huagongshe.com/reaction/217446
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | [(4-Isobutylphenyl)ethynyl](trimethyl)silane | HCID 58438693 | — |
| 반응물 | 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate | HCID 86657642 | — |
| 촉매 | Cupric Chloride | HCID 24014 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde | HCID 58438685 | 23.8% |
반응 단계
To a solution of copper chloride (10 mg) and Pd(PPh3)4 (60 mg) in DMF (2 mL) were added [(4-isobutylphenyl)ethynyl](trimethyl)silane (288 mg) and 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate (340 mg) at room temperature, followed by stirring at 80° C. for 12 hours. The reaction liquid was concentrated and the residue was purified by silica gel column chromatography (CHCl3) to obtain 5-fluoro-7-[(4-isobutylphenyl)ethynyl]-2H-chromene-3-carbaldehyde (83 mg) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08193378B2 |
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| 출처 데이터셋 | uspto-grants-2012_06 |
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| ORD ID | ord-2d1d4fcb25d646269e27f1f81a42f442 |
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| 출처 메모 | uspto-grants-2012_06 |
|---|
