2-Iodo-3-methylbenzoic acid → Methyl 2-iodo-3-methylbenzoate

반응식

[I:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:12](Cl)Cl.CO>>[I:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:12])=[O:5]

참가 물질

반응물 2

HCID 27593652-Iodo-3-methylbenzoic acid

HCID 21226129Dichloromethane methanol

생성물 1

HCID 13924925Methyl 2-iodo-3-methylbenzoate

실험 절차

2-iodo-3-methylbenzoic acid (595 mg, 2.27 mmol) was dissolved in DCM/MeOH=1/1 (5 ml) at 0° C., then TMS-CH2N2 (2M in Et2O, 1.4 ml, 2.8 mmol) was added. After 1.5 hours at RT solvents were evaporated. Yield 630 mg yellow oil.

후처리

customAfter 1.5 hours at RT solvents were evaporated

출처 및 근거

ORD 기록: ord-8262197c8ae54385a67703552e0e64e3
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09062033B2

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