Methanol → 2,3-Dimethyl 2,3-pyridinedicarboxylate

HRID 2174685

반응식

HRID 2174685 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([OH:9])=[O:8])[C:2]=1[C:10]([OH:12])=O.S(=O)(=O)(O)O.[C:18](=O)([O-])[O-].[Na+].[Na+].[CH3:24][OH:25]>>[CH3:24][O:25][C:10]([C:2]1[C:3]([C:7]([O:9][CH3:18])=[O:8])=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:12]

참가 물질

5

반응물 4

HCID 887MethanolHCID 1066Quinolinic AcidHCID 1118Sulfuric AcidHCID 10340Sodium Carbonate

생성물 1

HCID 690582,3-Dimethyl 2,3-pyridinedicarboxylate

실험 절차

To a solution of pyridine-2,3-dicarboxylic acid (50.0 g, 0.299 mol) in methanol (500 ml) was added con. sulfuric acid (20 ml). After heated to reflux for 24 hours, the mixture was basified with saturate sodium carbonate solution until pH=8 and then extracted with ethyl acetate. The combined extracts were washed with brine, dried over magnesium sulphate, filtered and evaporated to give D78 (45.7 g) as a white solid.

후처리

  1. temperatureAfter heated
  2. temperatureto reflux for 24 hours
  3. extractionextracted with ethyl acetate
  4. washThe combined extracts were washed with brine
  5. dry with materialdried over magnesium sulphate
  6. filtrationfiltered
  7. customevaporated
  8. customto give D78 (45.7 g) as a white solid

출처 및 근거

ORD 기록
ord-3b19b6432f254ab399d3b17d25803d23
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062033B2

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