Trifluoroacetic acid → (1S,6R)-8-Cbz-3,8-diazabicyclo[4.2.0]octane
반응식
[C@H:1]12[N:8]([C:9]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:10])[CH2:7][C@H:6]1[CH2:5][CH2:4][N:3](C(OC(C)(C)C)=O)[CH2:2]2.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C@H:1]12[N:8]([C:9]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:10])[CH2:7][C@H:6]1[CH2:5][CH2:4][NH:3][CH2:2]2참가 물질
4
실험 절차
To (1S,6R)-8-benzyl 3-tert-butyl 3,8-diazabicyclo[4.2.0]octane-3,8-dicarboxylate (300 mg, 0.9 mmol) in CH2Cl2 was added TFA (1:1). After 2 h, the reaction was concentrated and used without further purification.
후처리
- concentrationthe reaction was concentrated
- customused without further purification
출처 및 근거
- ORD 기록
- ord-b619a0c550e8467fbd8ad895002839d3
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09062044B2
반응 노트
불러오는 중…