Dimethylamine → HCID 58497419, 화합물

HRID 2175185노트

반응식

HRID 2175185 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([CH3:12])[CH:7]=[C:8]([CH3:11])[CH:9]=2)[C:4]([CH:13]=O)=[CH:3]1.[CH3:15][NH:16][CH3:17].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl>[CH3:15][N:16]([CH3:17])[CH2:13][C:4]1[C:5]2[C:10](=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=2[CH3:12])[N:2]([CH3:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 534339461,4,6-Trimethyl-1H-indole-3-carbaldehyde

생성물 1

HCID 58497419HCID 58497419, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1,4,6-trimethyl-1H-indole-3-carbaldehyde (875 mg, 4.7 mmol) in CH2Cl2 (30 mL) and dimethylamine (2.0 M solution in MeOH) (4.7 mL, 9.3 mmol) was added sodium triacetoxyborohydride (NaBH(OAc)3) (2.9 g, 14 mmol) at 0° C. Upon complete addition the cooling bath was removed and the reaction mixture was stirred at room temperature for 48 h. When the reaction was complete, the mixture was diluted with CH2Cl2 and washed with saturated NaHCO3. The layers were separated and the organic phase was dried over MgSO4, filtered and concentrated. The residue was used in the next step of the synthesis without purification.

후처리

  1. additionUpon complete addition the cooling bath
  2. customwas removed
  3. additionthe mixture was diluted with CH2Cl2
  4. washwashed with saturated NaHCO3
  5. customThe layers were separated
  6. dry with materialthe organic phase was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe residue was used in the next step of the synthesis without purification

출처 및 근거

ORD 기록
ord-d889cc2827704f0a89eb1f1c70ad2ff3
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062056B2

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