홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,1'-Carbonyldiimidazole → (R)-3-(2-Cyclopropyl-8-oxo-7,8-dihydro-purin-9-yl)-3-phenyl-propionic acid ethyl ester

HRID 2175203
노트
인쇄 미리보기

반응식

HRID 2175203 반응식
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C@@H:6]([NH:13][C:14]1[C:19]([NH2:20])=[CH:18][N:17]=[C:16]([CH:21]2[CH2:23][CH2:22]2)[N:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].C1N=CN([C:30](N2C=NC=C2)=[O:31])C=1>C1COCC1.C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C@@H:6]([N:13]1[C:30](=[O:31])[NH:20][C:19]2[C:14]1=[N:15][C:16]([CH:21]1[CH2:22][CH2:23]1)=[N:17][CH:18]=2)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 58497455(R)-3-(5-Amino-2-cyclopropyl-pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester

생성물 1

HCID 58497396(R)-3-(2-Cyclopropyl-8-oxo-7,8-dihydro-purin-9-yl)-3-phenyl-propionic acid ethyl ester수율 45%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate
용매

실험 절차

(R)-3-(5-Amino-2-cyclopropyl-pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester (880 mg, 2.7 mmol) was dissolved in THF (10 ml). To the solution CDI was added and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with Ethyl acetate (100 ml) washed with water, dried over MgSO4, filtered and evaporated to dryness. The black residue obtained was purified by chromatography, eluded with 3% methanol in dichloromethane to give oil (427 mg, 45%).

후처리

  1. washwashed with water
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. customevaporated to dryness
  5. customThe black residue obtained
  6. customwas purified by chromatography

출처 및 근거

ORD 기록
ord-bb8c2dd75210417980e1e74af084bf40
출처 데이터셋
uspto-grants-2015_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09062056B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트