Ethyl bromoacetate → Ethyl [(2,3-dimethylphenyl)oxy]acetate

HRID 2175226노트

반응식

HRID 2175226 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 106872,3-DimethylphenolHCID 10796Cesium carbonate

생성물 1

HCID 17065225Ethyl [(2,3-dimethylphenyl)oxy]acetate수율 100%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 2,3-dimethylphenol (1.0 g, 8.19 mmol), ethyl bromoacetate (1.0 mL, 9.0 mmol) and cesium carbonate (2.67 g, 8.19 mmol) in DMF (10 mL) was stirred at 80° C. for 16 h. After this time, the reaction mixture was partitioned between EtOAc and water. The organic layer was washed with water and brine, dried and concentrated in vacuo to afford the title compound (1.7 g, 100% yield). LCMS, [M+Na]+=231.0.

후처리

  1. customAfter this time, the reaction mixture was partitioned between EtOAc and water
  2. washThe organic layer was washed with water and brine
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1c90c4a7e41446c1a2644357b5cbedb8
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062028B2

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