3-((4-Bromo-1H-pyrazol-1-yl)methyl)benzamide → (3-((4-Bromo-1H-pyrazol-1-yl)methyl)phenyl)methanamine

반응식

BrC1C2C1CNC1C=CC=CC=12.BrC1C2C3CC3C(=O)NC=2C=CC=1.[Br:26][C:27]1[CH:28]=[N:29][N:30]([CH2:32][C:33]2[CH:34]=[C:35]([CH:39]=[CH:40][CH:41]=2)[C:36]([NH2:38])=O)[CH:31]=1>>[Br:26][C:27]1[CH:28]=[N:29][N:30]([CH2:32][C:33]2[CH:34]=[C:35]([CH2:36][NH2:38])[CH:39]=[CH:40][CH:41]=2)[CH:31]=1

참가 물질

반응물 3

HCID 470613323-((4-Bromo-1H-pyrazol-1-yl)methyl)benzamide

HCID 717427347-Bromo-3,7B-dihydro-1H-cyclopropa[C]quinolin-2(1AH)-one

HCID 86712576bromo-1a,2,3,7b-tetrahydro-1H-cyclopropa[c]quinoline

생성물 1

HCID 61036525(3-((4-Bromo-1H-pyrazol-1-yl)methyl)phenyl)methanamine

실험 절차

The title compound was prepared using a procedure analogous to bromo-1a,2,3,7b-tetrahydro-1H-cyclopropa[c]quinoline except that 7-bromo-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one was replaced with 3-((4-bromo-1H-pyrazol-1-yl)methyl)benzamide. LCMS, [M+H]+=266.1. 1H NMR (500 MHz, CDCl3) δ 7.47 (s, 1H), 7.36 (s, 1H), 7.33-7.25 (m, 2H), 7.18 (s, 1H), 7.09 (d, J=7.4 Hz, 1H), 5.24 (s, 2H), 3.85 (s, 2H), 1.78 (s, 2H).